Fields of Interest
The aim of our research project is the development of a safe chemotherapy to combat tropical parasitic diseases based on unique metabolic aspects of the etiological agents of these diseases such as Trypanosoma cruzi, T. brucei and Leishmania spp.
The selected targets to perform this project are pyrophosphate, ergosterol and trypanothione metabolisms. In the first case, bisphosphonate and other closely related compounds targeting farnesyl pyrophosphate synthase will be developed. The second target refers to the design of aryloxyethyl thiocyanates, which are potent inhibitors of T. cruzi growth targeting squalene synthase of the parasite. Finally, glutathionylspermidine synthase and trypanothione synthase catalyze the two ultimate steps of trypanothione biosynthesis, metabolite that is responsible of cellular redox control in trypanosomatids. These enzymes are not present in mammals and their inhibition would lead to potential chemotherapeutic agents.
The term carbanucleoside refers to a nucleoside analogue in which the furanosic oxygen atom has been replaced by a methylene group. The design and synthesis of carbanucleosides of pharmacological importance is one of the major interest of our group as well as the influence of sugar conformation on biological activity.