Member

Dr. Sergio H. Szajnman

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  • Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites
    Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, Maria N. Chao, Sergio H. Szajnman, Roberto Docampo, Silvia N. J. Moreno and Juan B. Rodriguez
    Molecules 2017, 22, 82 doi: 10.3390/molecules22010082


  • Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii
    Maria N. Chao, Catherine Li, Melissa Storey, Dr. Bruno N. Falcone, Dr. Sergio H. Szajnman, Prof. Dr. Sergio M. Bonesi, Prof. Dr. Roberto Docampo, Prof. Dr. Silvia N. J. Moreno, Prof. Dr. Juan B. Rodriguez
    ChemMedChem 2016, 1, 2690-2702 doi: 10.1002/cmdc.201600505


  • Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).
    Rodriguez JB, Falcone BN, Szajnman SH.
    Expert Opin. Ther. Pat. 2016, 29, 993-1015. doi: 10.1080/13543776.2016.1209487


  • Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase
    Rodriguez, Juan B., Falcone, Bruno N., Szajnman, Sergio H.
    Expert Opinion on Drug Discovery, 2016, 441, 307-320. doi: 10.1517/17460441.2016.1143814


  • Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii.
    Chao, M.N., Matiuzzi, C.E., Storey, M., Li, C., Szajnman, S.H., Docampo, R., Moreno, S.N.J., Rodriguez, J.B.
    ChemMedChem, 2015, 10, 1094-1108. doi: 10.1002/cmdc.201500100


  • New Insights into Molecular Recognition of 1,1-Bisphosphonic Acids by Farnesyl Pyrophosphate Synthase.
    Ferrer-Casal, M.;Li, C.; Galizzi, M.; Stortz, Carlos A.; Szajnman, Sergio H.; Docampo, Roberto; Moreno, Silvia N. J.; Rodriguez. Juan B.
    Bioorg. Med. Chem., 2014, 22, 398-405. doi: 10.1016/j.bmc.2013.11.010


  • Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.
    Recher, M; Borboza, A. P.; Li, Z.-H.; Galizzi, M.; Ferrer-Casal, M.; Szajnman, S. H.; Docampo, R.; Morena, S. N. J.; Rodriguez, J. B.
    Eup. J. Med. Chem., 2013, 60, 431-440. doi: 10.1016/j.ejmech.2012.12.015


  • 1,3-Dipolar cycloadditions on the versatile intermediate tetraethyl ethylidene bisphosphonate.
    Ferrer Casal, M.; Barboza, A. P.; Sergio H. Szajnman, S. H. and Rodriguez, J. B.
    Synthesis, 2013, 45, 2397-404. doi: 10.1055/s-0033-1338498


  • Design, Synthesis and Biological Evaluation of WC-9 Analogues as Antiparasitic Agents.
    Pablo Elicio, Maria N. Chao, Zhu-Hong Li, Melina Galizzi, Sergio H. Szajnman, Roberto Docampo, Silvia N. J. Moreno, and Juan B. Rodriguez.
    Eur. J. Med. Chem., 2013, 69, 480-489. doi: 10.1016/j.ejmech.2013.09.009


  • 1-(Fluoroalkylidene)-1,1-bisphosphonic Acids are Potent and Selective Inhibitors of the Enzymatic Activity of Toxoplasma gondii Farnesyl Pyrophosphate Synthase.
    Szajnman, S. H., Rosso, V. S., Malayil, L., Smith, A., Moreno, S. N. J., Docampo, R., Rodriguez, J. B.;
    Org. Biomol. Chem., 2012, 10, 1424-33. doi: 10.1039/c1ob06602a


  • New antibacterials for the treatment of toxoplasmosis; a patent review.
    Rodriguez, J.B., Szajnman, S.H.
    Expert Opin Ther Pat. 2012, 22, 311-33. doi: 10.1517/13543776.2012.668886


  • Trypanosoma cruzi Squalene Synthase is a Major Target for 2-Alkylaminoethyl-1,1-Bisphosphonates.
    Carlos Poveda, Dolores Gonzalez-Pacanowska, Sergio H. Szajnman, and Juan B. Rodriguez,
    Antimicrob. Agents Chemother. 2012, 56, 4483-4486. doi: 10.1128/AAC.00796-12


  • Design, Synthesis, Calorimetry and Crystallographic analysis of 2-Alkylaminoethyl-1,1-Bisphosphonates as inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase.
    Srinivas Aripirala, Sergio H. Szajnman, Jean Jakoncic, Juan B. Rodriguez, Roberto Docampo, Sandra B. Gabelli, and L. Mario Amzel,
    J. Med. Chem. 2012, 55, 6445-6454. doi: 10.1021/jm300425y


  • Synthesis and Biological Evaluation of New 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase.
    V. S. Rosso, S. H. Szajnman, L. Malayil, M. Galizzi, S. N. J. Moreno, R. Docampo, and J. B. Rodriguez.
    Bioorg. Med. Chem. 2011, 19, 2211-2217. doi: 10.1016/j.bmc.2011.02.037


  • Electron Transfer Dynamics of Rhodotermus marinus caa3 Cytochrome c Domain on Biomimetic Films.
    M. F. Molinas, A. De Candia, S. H. Szajnman, J. B. Rodriguez, M. Marti, S. Todorovic, and D. H. Murgida.
    Phys. Chem. Chem. Phys. 2011, 13, 18088-18098. doi: 10.1039/c1cp21925a


  • Synthesis and Biological Evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase.
    S. H. Szajnman, G. E. Garcia Linares, Zhu-Hong Li, Melina Galizzi, Cuiying Jiang, E. Bontempi,M. Ferella, S. N. J. Moreno, R. Docampo and J. B. Rodriguez.
    Bioorg. Med. Chem. 2008, 16, 3283-3290. doi: 10.1016/j.bmc.2007.12.010


  • Synthesis and Biological Evaluation of 1-Amino-1,1-Bisphosphonates Derived from Fatty Acids against Trypanosoma cruzi targeting Farnesyl Pyrophosphate Synthase.
    S. H. Szajnman, E. L. Ravaschino, R. Docampo and J. B. Rodriguez
    Bioorg. Med. Chem. Lett. 2005, 15, 4685-4690. doi: 10.1016/j.bmcl.2005.07.060


  • New Insights into the Chemistry of gem-Bis(phosphonates): Unexpected Rearrangement of Michael-type Acceptors.
    S. H. Szajnman, G. Garcia Linares, P. Moro and J. B. Rodriguez
    Eur. J. Org. Chem. 2005, 3687-3696. doi: 10.1002/ejoc.200500097


  • Bisphosphonates Derived from Fatty Acids are Potent Inhibitors of Trypanosoma cruzi
    Farnesyl Pyrophosphate Synthase.
    S. H. Szajnman, A. Montalvetti, Y. Wang, R. Docampo and J. B. Rodriguez
    Bioorg. Med. Chem. Lett. 2003, 13, 3231-3235. doi: 10.1016/S0960-894X(03)00663-2


  • Design, Synthesis and Biological Evaluation of Aryloxyethyl Thiocyanate Derivatives against Trypanosoma cruzi.
    E. Elhalem, B. N. Bailey, R. Docampo, I. Ujvary, S. H. Szajnman and J. B. Rodriguez
    J. Med. Chem. 2002, 45, 3984-3999. doi: 10.1021/jm0201518


  • Design and Synthesis of Aryloxyethyl Thiocyanate Derivatives as Potent Inhibitors of Trypanosoma cruzi Proliferation.
    S. H. Szajnman, W. Yan, B. N. Bailey, R. Docampo, E. Elhalem and J. B. Rodriguez
    J. Med. Chem. 2000, 43, 1826-1840. doi: 10.1021/jm9905007


  • Structure-Activity Relationship of New Growth Inhibitors of Trypanosoma cruzi.
    G. M. Cinque, S. H. Szajnman, L. Zhong, R. Docampo, A. J. Schvartzapel, J. B. Rodriguez and E. G. Gros.
    J. Med. Chem. 1998, 41, 1540-1554.