Welcome to Pablo H. Di Chenna`s Group site

Research and Publications


 Current Research Area 
Physical gels based on low molecular weight gelators (LMWG) and a liquid (organic solvent or water) are formed through cooperative non covalent supramolecular interactions leading to a 3D self-assembled network that traps the solvent. Their relevance is related to their unique properties as functional materials and their many potential high-tech applications. The formation of the gel involves a delicate balance of cooperative forces between the directional self-assembly that promotes the aggregation and the solubility in the given solvent, which is based on the specific interactions between solvent and gelator molecules. Although a great effort has been made to investigate the structure–property relationships and the gelation process, it is still not possible to design a new LMOG de novo and the gelation process is poorly understood.
Our research interests are focused on the rational development of new low molecular weight gelators and the study and characterization of their functional gels. The research project involves from the design and synthesis of new small molecular weight gelators to the physicochemical characterization of their gels. The main goal is to understand the structure-property relationship in order to rationally design new LMOGs and create functional soft materials with interesting chemical and/or physical properties. In particular our current research is centered on aromatic pi-gelators, the study of their electronic associated properties (fluorescence, electric conductivity, etc.) and their use as molecular template for the preparation of inorganic nanostructured materials such as fibers, ribbons, sheets, helical structures, etc.

   Publications

Steroids
2017, 121, 40-56. https://authors.elsevier.com/a/1UlVX,uy65TEZ
Virginia Dansey, Celeste Del Fueyo, Adriana S. Veleiro, Pablo H. Di Chenna
Synthesis of new C-25 and C-26 steroidal acids as potential ligands of the nuclear receptors DAF-12, LXR and GR. 
DOI:10.1016/j.steroids.2017.03.003

J. Mater. Chem. C, 2016, 4, 7035-7042.
Luciana C. Schmidt, Valeria C. Edelsztein, Carla C. Spagnuolo, Pablo H. Di Chenna, Raquel E. Galian
Light-responsive hybrid material based on luminescent core-shell quantum dots and steroidal organogel.
doi: 10.1039/C6TC02265K

Gels
2016, 2(1), 7
Ignacio Muñoz Resta, Verónica E. Manzano, Florencia Cecchi, Carla C. Spagnuolo, Fabio D. Cukiernik , Pablo H. Di Chenna.
Supramolecular Assembly of pH Sensitive Triphenylene Derived pi-Gelators and Their Application as Molecular Template for the Preparation of Silica Nanotubes. 
doi:10.3390/gels2010007 

ACS Appl. Mater. Interfaces. 2014, 6, 8933−8936 
Bonifazi, Evelyn; Edelsztein, Valeria; Menendez, Guillermo; Samaniego López, Cecilia; Spagnuolo, Carla; Di Chenna, Pablo H.
Versatile Supramolecular Organogel with Outstanding Stability towards Aqueous Interfaces. 
doi10.1021/am5010656
 
Beilstein J. Org. Chem. 2013, 9, 1826-1836 
V. C. Edelsztein, A. S. Mac Cormack, M. Ciarlantini, P. H. Di Chenna
Self-assembly of 2,3-Dihydroxycholestane Steroids into Supramolecular Organogels as a Soft Template for the in-situ Generation of Silicate Nanomaterials.  
doi10.3762/bjoc.9.213

Steroids 2013, 78, 34-36 
M. D. Martinez, V. C. Edelsztein, F. J. Duran, P. H. Di Chenna, G. Burton.
Synthesis of 6-Azaprogesterone and 19-Hydroxy-6-azasteroids
doi10.1016/j.steroids.2012.10.012

J. Mat. Chem. 2012, 22, 21857-21861 
Valeria C. Edelsztein, Elizabeth A. Jares-Erijman, Klaus Müllen, Pablo H. Di Chenna, 
Carla C. Spagnuolo Título: A Luminescent Steroid-Based Organogel: ON–OFF Photoswitching by Dopant Interplay and Templated Synthesis of Fluorescent Nanoparticles. 
doi:  10.1039/C2JM34891H

Bioorg. And Med. Chem. 2011, 19(5), 1683-1691 
Alvarez, L.D., Dansey, M.V., Martí, M.A., Bertucci, P.Y., Di Chenna, P.H., Pecci, A., Burton, G.
Biological Activity and Ligand Binding Mode to the Progesterone Receptor of A-homo Analogues of Progesterone. 
doi10.1016/j.bmc.2011.01.033

Tetrahedron: Asymmetry., 2010, 21, 1447-1457. 
Fabien Robert-Peillard, Pablo H. Di Chenna, Chungen Liang, Camille Lescot, Florence Collet, Robert H. Dodd, Philippe Dauban.
Catalytic Stereoselective Alkene Aziridination with Sulfonimidamides. 
doi10.1016/j.tetasy.2010.03.032

European J. Med. Chem., 2010, 45, 3063-3069 
M. Dansey, P.H. Di Chenna, A.S. Veleiro, Z. Krištofíková, H. Chodounska, A. Kasal, G. Burton.
Synthesis and GABAA Receptor Activity of A-Homo Analogues of Neuroactive Steroids. 
doi10.1016/j.ejmech.2010.03.037

Tetrahedron, 2010, 66, 2162-2167 
Edelsztein, V. C.; Burton, G.; Di Chenna, P.H. 
Self-assembly of a Silylated Steroid Organogelator and its Use as Template for the in situ Sol-Gel Polymerization of Tetraethyl orthosilicate  
  doi: 10.1016/j.tet.2010.01.065

Tetrahedron, 2009, 65, 3615-3623 
Edelsztein, V. C.; Di Chenna, P. H.; Burton, G. 
Synthesis of C-C bonded dimeric steroids by olefin metathesis 
doi10.1016/j.tet.2009.03.006

Org. Biomol. Chem., 2007, 5, 2453-2457 
Pablo H. Di Chenna, Adriana S. Veleiro, Juan M. Sonego, Nora R. Ceballos, M. Teresa Garland, Ricardo F. Baggio, Gerardo Burton 
Synthesis of 6,19-cyclopregnanes. Constrained Analogues of Steroid Hormones 
doi:  10.1039/B706828J

Arkivoc, 2005, xii, 154-162 
P.H. Di Chenna, M.V. Dansey, A. Ghini, G. Burton 
Rearrangement of 4b,5b-methylenepregnanes: a simple approach to A-homopregnanes and 5 a -methylpregnanes. 
 http://www.arkat-usa.org/get-file/19350/

Tetrahedron Lett. 2005, 46, 4235-4238 
A.S. Veleiro, P.J. Taich, L.D. Alvarez, P.H. Di Chenna, G. Burton 
Synthesis of C(1)-C(11) Oxygen-Bridged Pregnanes 
  doi: 10.1016/j.tetlet.2005.04.052

Org. Lett., 2004, Vol. 6, 24, 4503-4505 
P.H. Di Chenna , F. Robert-Peillard, P. Dauban, R.H. Dodd 
Sulfonimidamides: Efficient Chiral Iminoiodane Precursors for Diastereoselective Copper-Catalized Aziridination of Olefines
doi10.1021/ol048167a

Tetrahedron, 2003, 59, 1009-1014 
P.H. Di Chenna, P. Dauban, A. Ghini, R. Baggio, M. T. Garland, G. Burton, R. H. Dodd 
PhI=Nses Mediated Aziridination of 11-Pregnane Derivatives: Synthesis of an 11,12-Aziridino Analogue of Neuroactive Steroids. 
doi: 10.1016/S0040-4020(02)01655-1
 
 J. Chem. Soc. Perkin Trans I, 2002, 2, 227-231 
P.H. Di Chenna, A. Ferrara, A. Ghini y G. Burton,  
Cleavage of Cyclopropyl Ketones Mediated by Alkyl Mercury(II)  
doi10.1039/B107258G

J. med. Chem., 2001, Vol44, 15, 2486-2489 
P.H. Di Chenna, V. Benedetti-Doctorovich, R.F. Baggio, M. T. Garland, Gerardo Burton.  
Preparation and Cytotoxicity toward Cancer Cells of Mono(arylimino) Derivatives  of b-Lapachone 
doi10.1021/jm010050u

Tetrahedron letters, 2000, 41, 7041-7045 
 P.H. Di Chenna, P. Dauban, A. Ghini, G. Burton, R. H. Dodd
 Aziridination of 11-Pregnene-3,20-dione Using PhI=N-Ses. 
doi10.1016/S0040-4039(00)01228-4

Recent and ongoing projects

Ongoing Projects:
- Design, synthesis and study of low molecular weight organogelators oriented to the preparation of inorganic and hybrid nanostructured materials

- Design, synthesis and study of pi-gelators and the characterization of their electronic properties.

Recent Projects
-Design, synthesis and characterization of steroidal supramolecular gelators.

          Selected Publications
-------------------------------------------------
Gels 2016, 2(1), 7
Beilstein J. Org. Chem. 2013, 9, 1826-1836
J. Mat. Chem. 2012, 22, 21857-21861